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Construction of An Indium-Modified Weakly Alkaline Aqueous Iron-Chromium Redox Flow Battery and Its Energy Storage Performance
LIU Yingying;ZHANG Xiaofei;LUO Jingyao;ZHU Zonghan;FENG Qinghao;LIU Xueyi;LI Yafei;XIE Xiaoyin;DENG Xiangyi;We prepared a CrPDTA chelate by the chelation reaction of PDTA with chromium ion,obtained an indium-modified graphite felt electrode by modifying graphite felt electrode with indium chloride, and characterized the CrPDTA chelate and indium-modified graphite felt electrode by FTIR,UV-Vis,SEM,and EDS.Moreover,we assembled an indium-modified weakly alkaline aqueous iron-chromium redox flow battery(InICRFB) by using indium-modified graphite felt electrode,K4 Fe(CN)6 as a positive electrolyte and CrPDTA as a negative electrolyte,and systematically investigated the effects of indium-modified graphite felt electrode on the key performance indicators of the battery,such as energy efficiency,voltage efficiency,and capacity retention rate,etc.Furthermore,we preliminarily explored the internal mechanism of the performance enhancement.The results show that there is a chelation between PDTA and chromium ions,and indium is uniformly attached to the surface of graphite felt electrode.Indium plays a key role in improving the electrode conductivity and reducing charge transfer losses.Compared with the pristine ICRFB,In-ICRFB has the better battery performance:after 200 charge-discharge cycles at a current density of 50 mA·cm-2,the Coulomb efficiency is about 99.0%,the energy efficiency is 81.4%,the voltage efficiency is 82.2 %,the capacity retention rate is 35.0 %,and the average capacity degradation rate of single cycle is 0.325%.
Anti-Breast Cancer Active Components in Loquat Leaves and Their Inhibitory Effects on Topoisomerase Ⅰ
LIU Jiayao;YANG Junlong;XIE Yuman;HUANG Hui;ZENG Huang;NIE Hua;GUO Bohong;In order to explore the anti-breast cancer active components in loquat leaves and their inhibitory effects on topoisomerase Ⅰ(TOP Ⅰ),we integrated network pharmacology to screen the anti-breast cancer active components from loquat leaves and core pathways.Moreover,we analyzed the interaction mode and inhibitory efficacy of the active components with TOP Ⅰ by using molecular docking and TOP Ⅰ-mediated DNA relaxation experiments.Furthermore,we investigated the effects of the active components on the proliferation,migration,cloning,and apoptosis of human breast cancer cells MCF-7 by cytotoxicity experiments,cell scratch healing experiments,cell cloning experiments,and cell apoptosis experiments.The results show that quercetin,ellagic acid,(-)-epigallocatechin gallate,and kaempferol are the key anti-breast cancer active components in loquat leaves,they can stably bind to the catalytic domain of TOP Ⅰ.All four active components can inhibit the activity of TOP Ⅰ in a concentration-dependent manner.The half-maximal inhibitory concentrations(IC50) of the four active components are 160.70,84.82,72.54,and 80.67 μmol·L-1,respectively,significantly inhibiting the growth,proliferation,migration,and cloning of MCF-7 cells and promoting cell apoptosis.This study provides a theoretical basis for the research of antitumor activity of loquat leaves extracts.
Research Progress in Carbon-Based Catalysts Modification Strategies and Electrochemical Reactor for Synthesis of H_2O2 via 2e-ORR
LU Zilan;JIA Daqing;HU Huawei;ZHU Leilei;KHAN Asim;XU Wenxuan;LIAO Benren;ZHANG Lehua;The synthesis of hydrogen peroxide(H_2O2) via two-electron oxygen reduction reaction(2e-ORR) has become a new and sustainable alternative to industrial anthraquinone process due to its advantages of normal temperature and pressure operation,green raw materials,and renewable energy.Based on the brief explanation of synthetic mechanism of H_2O2 via 2e-ORR,we review the modification strategies of carbon-based catalysts,including heteroatom doping,defect engineering,functional groups,etc.At the same time,we summarize the structure characteristics and application scenarios of H-type,flow-type,and membrane electrode assembly(MEA) reactors,and point out the challenges faced by the current technology,which provides a theoretical support for the research of H_2O2 synthesis via 2e-ORR.
Preparation and in vitro Dissolution of Imatinib Liposomes
LIU Chunyu;HU Xuelei;In response to the problems of poor solubility,low oral bioavailability,and adverse reactions caused by Imatinib,we prepared Imatinib liposomes by passive drug-loading and active drug-loading processes,respectively.Moreover,we optimized the process parameters through single-factor experiments by using the encapsulation efficiency as an indicator.Furthermore,we systematically studied the microscopic morphology,particle size,Zeta potential,in vitro release behavior,and stability of Imatinib liposomes.The results show that,in the passive drug-loading process, the encapsulation efficiency of Imatinib liposomes prepared by film dispersion method is the highest[(67.0±2.4)%];in the active drug-loading process,under the conditions of the drugloading time of 40 min,the drug-loading temperature of 50 ℃,the drug-lipid ratio of 1:30,the transmembrane pH gradient of 5,and the ammonium sulfate concentration of 100 mmol·L-1,the encapsulation efficiency of Imatinib liposomes is the highest[(65.0±4.1) %].The liposomes prepared by both two processes have regular morphology,spherical or nearly spherical shapes,with a particle size of 100-110 nm,showing good dispersion.The Imatinib liposomes prepared by the active drug-loading process exhibit good sustained-release effect in vitro and have better stability at 4 ℃ refrigeration than that at room temperature.The study lays a foundation for the development of a new drug delivery system for Imatinib.