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We co-cultured two algicolous Trichoderma strains(Trichoderma virens and Trichoderma longibrachiatum) isolated from Zhoushan Sea area, and obtained eight compounds through separation and purification of their crude fermentation extracts by using reverse-phase silica gel column chromatography, silica gel column chromatography, and gel column chromatography.Based on ~1HNMR,13CNMR analysis, and comparison with literature data, these compounds are identified as CAF-603(1),trichocarane A(2),trichocarotin H(3),trichocarotin N(4),7-β-hydroxy CAF-603(5),trichocarotin Ⅰ(6),(3R,5R)-3,5-dihydroxydecanoic acid(7),and 3,5-dihydroxydecanoic acid methyl ester(8).
[1] 黄瑞环，韩小斌，刘京，等.海洋曲霉和海洋木霉抗植物病原菌活性次级代谢产物研究进展[J].江苏农业学报，2020,36(5):1332-1341.HUANG R H,HAN X B,LIU J,et al.Research progress on secondary metabolites with anti-phytopathogenic activities of marine-derived Aspergillus sp.and Trichoderma sp.[J].Jiangsu Journal of Agricultural Sciences,2020,36(5):1332-1341.
[2] 杨曦亮，任梦瑶，刘倩，等.近十年海洋来源木霉属真菌次生代谢产物研究进展[J].广西科学，2021,28(5):440-450.YANG X L,REN M Y,LIU Q,et al.Research progress on secondary metabolites from marine-derived Trichoderma sp.in the past decade[J].Guangxi Sciences,2021,28(5):440-450.
[3] SONG Y P,JI N Y.Chemistry and biology of marine-derived Trichoderma metabolites[J].Natural Products and Bioprospecting,2024,14(1):14.
[4] PETTIT R K.Mixed fermentation for natural product drug discovery[J].Applied Microbiology and Biotechnology,2009,83(1):19-25.
[5] KNOWLES S L,RAJA H A,ROBERTS C D,et al.Fungal-fungal co-culture:a primer for generating chemical diversity[J].Natural Product Reports,2022,39(8):1557-1573.
[6] WATANABE N,YAMAGISHI M,MIZUTANI T,et al.CAF-603:a new antifungal carotane sesquiterpene:isolation and structure elucidation[J].Journal of Natural Products,1990,53(5):1176-1181.
[7] MACÍAS F A,VARELA R M,SIMONET A M,et al.Bioactive carotanes from Trichoderma virens[J].Journal of Natural Products,2000,63(9):1197-1200.
[8] SHI Z Z,FANG S T,MIAO F P,et al.Trichocarotins A-H and trichocadinin A,nine sesquiterpenes from the marine-alga-epiphytic fungus Trichoderma virens[J].Bioorganic Chemistry,2018,81:319-325.
[9] YANG W T,GAO W,LIU J A,et al.Trichocarotin N:a new carotane sesquiterpene from the marine-derived fungus Trichoderma virens QD-11[J].Records of Natural Products,2022,17(2):363-366.
[10] YASUMURA R,ASHTEKAR K D,TONOUCHI A,et al.7-β- and 10-β-hydroxylated congeners of CAF-603;elucidation of absolute configuration of CAF-603 family,and their SAR studies in the anti-fungal activity[J].Tetrahedron,2013,69(45):9469-9474.
[11] SHI X S,SONG Y P,MENG L H,et al.Isolation and characterization of antibacterial carotane sesquiterpenes from Artemisia argyi associated endophytic Trichoderma virens QA-8[J].Antibiotics,2021,10(2):213.
[12] CHOI H G,KIM J W,CHOI H,et al.New hydroxydecanoic acid derivatives produced by an endophytic yeast Aureobasidium pullulans AJF1 from flowers of Aconitum carmichaeli[J].Molecules,2019,24(22):4051.
[13] 邹积雪，季乃云.松节藻来源长枝木霉DL5-4化学成分及其生物活性研究[J].化学与生物工程，2019,36(3):13-17.ZOU J X,JI N Y.Chemical constituents of Trichoderma longibrachiatum DL5-4 from marine red alga Rhodomela confervoides and their bioactivities[J].Chemistry & Bioengineering,2019,36(3):13-17.
[14] 邹积雪.三株海洋真菌次生代谢产物及其生物活性研究[D].烟台：中国科学院大学(中国科学院烟台海岸带研究所),2019.ZOU J X.Secondary metabolites from three marine-derived fungi and their bioactivities[D].Yantai:University of Chinese Academy of Sciences(Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences),2019.
[15] XUE S J,LIU G L,CHI Z,et al.Genetic evidences for the core biosynthesis pathway,regulation,transport and secretion of liamocins in yeast-like fungal cells[J].Biochemical Journal,2020,477(5):887-903.
[16] KANG X X,JIA S L,WEI X,et al.Liamocins biosynthesis,its regulation in Aureobasidium spp.,and their bioactivities[J].Critical Reviews in Biotechnology,2022,42(1):93-105.
[17] ABDEL-LATEFF A,ELKHAYAT E S,FOUAD M A,et al.Aureobasidin,new antifouling metabolite from marine-derived fungus Aureobasidium sp.[J].Natural Product Communications,2009,4(3):389-394.
Basic Information:
China Classification Code:Q939.9;O629
Citation Information:
[1]ZHANG Wei,SHI Zhenzhen,JI Naiyun.Secondary Metabolites from Co-Culture of Two Algicolous Trichoderma Strains[J].Chemistry ＆ Bioengineering,2026,43(08):32-36.
Fund Information:
国家自然科学基金项目(42206130)
2026-08-04
2026-08-04