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Using carboxymethyl chitosan(CMCS) and oxidized konjac glucomannan(OKGM) as raw materials,we prepared a CMCS/OKGM composite sponge by a freeze-drying method.Moreover,we characterized the structure by FTIR,~1HNMR,and SEM.Furthermore,we evaluated the performance by water absorption,porosity,air permeability,NIH-3 T3 cell proliferation test,antibacterial ability,and acute systemic toxicity test.The results show the optimal preparation process of CMCS/OKGM composite sponge is determined as follows:firstly,OKGM is prepared by oxidation of sodium periodate;then,5% CMCS solution is mixed with 5% OKGM solution according to the volume ratio of 5∶5,and 2% glycerin is added as a plasticizer;finally,the composite sponge is obtained by freezing and drying.The CMCS/OKGM composite sponge has good water absorption,porosity,air permeability,antibacterial activity,and biosafety,and can promote proliferation of epidermal cells.CMCS/OKGM composite sponge is an excellent base material for medical chronic wound dressing.
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Basic Information:
China Classification Code:R318.08;TQ314
Citation Information:
[1]LI Jie,XU Jianzhen,HU Ping ,et al.Preparation and Performance Evaluation of Carboxymethyl Chitosan/Oxidized Konjac Glucomannan Composite Sponge[J].Chemistry ＆ Bioengineering,2020,37(08):5-12.
Fund Information:
广东省科技厅科技计划项目(2017A020211006); 国家自然科学基金项目(20976068)
2020-08-14
2020-08-14