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The first part of this paper focuses on reviewing the methods of synthesizing polypeptides from two aspects: chemosynthesis and biosynthesis.Especially the methods which developed in recent years,such as: N-carboxyanhydrides(NCA),peptide liquid-phase segments ligation,combinatorial chemistry,enzymatic hydrolysis,gene engineering,fermenting and so on are taken as examples.After describing the method,the relative merits of each method are appreciated.At the second part of the paper,the applications in polypeptide drugs,drug carrier,tissue engineering and enriched food are summarized.At last,the prospect of polypeptide industry in China is forecast.
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Basic Information:
China Classification Code:TQ464.7
Citation Information:
[1]LI Yong-zhen1,2,HE Ji-dong2,PENG Zheng1,LI Xi-juan3(1.Key Laboratory of Rubber-Plastics,Ministry of Education,Qingdao University of Science and Technology,Qingdao 266042,China, 2.Key Laboratory of Tropical Crop Products Processing,Ministryof Agriculture of China,Agro-Food Processing Institute,Chinese Academy of Tropical Agricultural Sciences,Zhanjiang 524001,China,3.Rubber Research Institute,Chinese Academy of Tropical Agricultural Sciences,Danzhou 571700,China).Progress in Synthesis and Applications of Polypeptides[J].Chemistry ＆ Bioengineering,2010,27(04):9-14.
Fund Information:
中国热带农业科学院橡胶研究所2009年基本科研业务费项目(2009-014N)
2010-04-25
2010-04-25