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The key to repairing tissue defects lies in timely closure of the wound and hemostasis.Traditional clinical approaches including surgical suture, staple suture, etc. are associated with limitations such as the secondary surgical removal, inadequate sealing, susceptibility to scarring, low adhesive strength, and suboptimal biocompatibility.Adhesive hydrogels are three-dimensional polymer network materials, which have developed rapidly in recent years.Due to strong adhesion, excellent biocompatibility, and degradability, adhesive hydrogels have solved the problems existing in traditional clinical approches and promoted the development and application in the field of tissue defect repair.We elaborate the mechanism of adhesion between hydrogel and tissue, including physical, chemical, and mussel-inspired effects.Then, we summarize the research progress of adhesive hydrogels in the defect repair of various tissues such as skin, periodontal, bone, heart, and cornea in recent years.Finally, we analyze the challenges faced by adhesive hydrogels, and put forward prospects for the future development directions.
[1] HAN S Y,AN S,CHO S W.Advanced bioadhesive hydrogels for skin care and therapy[J].Advanced Therapeutics,2024,7(1):2300125.
[2] GOH M,DU M,PENG W R,et al.Advancing burn wound treatment:exploring hydrogel as a transdermal drug delivery system[J].Drug Delivery,2024,31(1):2300945.
[3] LI S X,MA X D,ZHANG Y X,et al.Applications of hydrogel materials in different types of corneal wounds[J].Survey of Ophthalmology,2023,68(4):746-758.
[4] SALUDAS L,PASCUAL-GIL S,PRÓSPER F,et al.Hydrogel based approaches for cardiac tissue engineering[J].International Journal of Pharmaceutics,2017,523(2):454-475.
[5] KOVÁC J,PRIŠCÁKOVÁ P,GBELCOVÁ H,et al.Bioadhesive and injectable hydrogels and their correlation with mesenchymal stem cells differentiation for cartilage repair:a mini-review[J].Polymers,2023,15(21):4228.
[6] GUO S,YAO M H,ZHANG D,et al.One-step synthesis of multifunctional chitosan hydrogel for full-thickness wound closure and healing[J].Advanced Healthcare Materials,2022,11(4):2101808.
[7] BARKAN Y,LEVINMAN M,VEPRINSKY-ZUZULIYA I,et al.Comparative evaluation of polycyanoacrylates[J].Acta Biomaterialia,2017,48:390-400.
[8] BORIE E,ROSAS E,KURAMOCHI G,et al.Oral applications of cyanoacrylate adhesives:a literature review[J].BioMed Research International,2019,2019(1):8217602.
[9] BAYER I S.Advances in fibrin-based materials in wound repair:a review[J].Molecules,2022,27(14):4504.
[10] SHEN C,LI Y J,MENG Q.Adhesive polyethylene glycol-based hydrogel patch for tissue repair[J].Colloids and Surfaces B:Biointerfaces,2022,218:112751.
[11] OKATA S,HOSHINA K,HANADA K,et al.Hemostatic capability of a novel tetra-polyethylene glycol hydrogel[J].Annals of Vascular Surgery,2022,84:398-404.
[12] WANG B X,XU W,YANG Z C,et al.An overview on recent progress of the hydrogels:from material resources,properties,to functional applications[J].Macromolecular Rapid Communications,2022,43(6):2100785.
[13] BERRADI A,AZIZ F,EL-ACHABY M,et al.A comprehensive review of polysaccharide-based hydrogels as promising biomaterials[J].Polymers,2023,15(13):2908.
[14] ABDULGHANI S,MITCHELL G R.Biomaterials for in situ tissue regeneration:a review[J].Biomolecules,2019,9(11):750.
[15] LI X L,XU M F,GENG Z L,et al.Functional hydrogels for the repair and regeneration of tissue defects[J].Frontiers in Bioengineering and Biotechnology,2023,11:1190171.
[16] DING Q,ZHANG S,LIU X,et al.Hydrogel tissue bioengineered scaffolds in bone repair:a review[J].Molecules,2023,28(20):7039.
[17] MFOAFO K,OMIDI Y,OMIDIAN H.Thermoresponsive mucoadhesive hybrid gels in advanced drug delivery systems[J].International Journal of Pharmaceutics,2023,636:122799.
[18] JUNG H,KIM M K,LEE J Y,et al.Adhesive hydrogel patch with enhanced strength and adhesiveness to skin for transdermal drug delivery[J].Advanced Functional Materials,2020,30(42):2004407.
[19] LU Y J,LI Z H,LI Z W,et al.Fabrication of a tough,long-lasting adhesive hydrogel patch via the synergy of interfacial entanglement and adhesion group densification[J].Nanoscale,2024,16(2):645-656.
[20] HUANG Q T,ZOU Y J,ARNO M C,et al.Hydrogel scaffolds for differentiation of adipose-derived stem cells[J].Chemical Society Reviews,2017,46(20):6255-6275.
[21] PEI X J,WANG J T,CONG Y,et al.Recent progress in polymer hydrogel bioadhesives[J].Journal of Polymer Science,2021,59(13):1312-1337.
[22] WANG R X,LIU L Q,HE X,et al.Dynamic crosslinked injectable mussel-inspired hydrogels with adhesive,self-healing,and biodegradation properties[J].Polymers,2023,15(8):1876.
[23] YANG J W,BAI R B,CHEN B H,et al.Hydrogel adhesion:a supramolecular synergy of chemistry,topology,and mechanics[J].Advanced Functional Materials,2020,30(2):1901693.
[24] XU Y T,HU J F,HU J J,et al.Bioinspired polydopamine hydrogels:strategies and applications[J].Progress in Polymer Science,2023,146:101740.
[25] ZHANG D F,XU Z Y,LI H F,et al.Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities[J].Biomaterials Science,2020,8(5):1455-1463.
[26] WANG X D,GUO Y X,LI J F,et al.Tough wet adhesion of hydrogen-bond-based hydrogel with on-demand debonding and efficient hemostasis[J].ACS Applied Materials & Interfaces,2022,14(31):36166-36177.
[27] VILLIOU M,PAEZ J I,del CAMPO A.Photodegradable hydrogels for cell encapsulation and tissue adhesion[J].ACS Applied Materials & Interfaces,2020,12(34):37862-37872.
[28] ZHENG S Q,CHEN X L,SHEN K X,et al.Hydrogen bonds reinforced ionogels with high sensitivity and stable autonomous adhesion as versatile ionic skins[J].ACS Applied Materials & Interfaces,2024,16(3):4035-4044.
[29] CONG Y,FU J.Hydrogel-tissue interface interactions for implantable flexible bioelectronics[J].Langmuir,2022,38(38):11503-11513.
[30] XU M D,MIAO Y,YU J H,et al.Physiologically-regulated adhesion of hydrogels for wound dressing[J].Advanced Materials Interfaces,2021,8(20):2101131.
[31] SU X,LUO Y,TIAN Z L,et al.Ctenophore-inspired hydrogels for efficient and repeatable underwater specific adhesion to biotic surfaces[J].Materials Horizons,2020,7(10):2651-2661.
[32] FU C,SHEN L L,LIU L Q,et al.Hydrogel with robust adhesion in various liquid environments by electrostatic-induced hydrophilic and hydrophobic polymer chains migration and rearrangement[J].Advanced Materials,2023,35(15):2211237.
[33] YANG J W,BAI R B,SUO Z G.Topological adhesion of wet materials[J].Advanced Materials,2018,30(25):1800671.
[34] PENG X,XIA X F,XU X Y,et al.Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations[J].Science Advances,2021,7(23):eabe8739.
[35] LIANG Y Q,LI Z L,HUANG Y,et al.Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing[J].ACS Nano,2021,15(4):7078-7093.
[36] CHEN J Q,YANG J B,WANG L,et al.Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration[J].Bioactive Materials,2021,6(6):1689-1698.
[37] LI M,SHI X L,YANG B,et al.Single-component hyaluronic acid hydrogel adhesive based on phenylboronic ester bonds for hemostasis and wound closure[J].Carbohydrate Polymers,2022,296:119953.
[38] XU Z J,LIU G T,LIU P,et al.Hyaluronic acid-based glucose-responsive antioxidant hydrogel platform for enhanced diabetic wound repair[J].Acta Biomaterialia,2022,147:147-157.
[39] TANG Z Q,LIU Z,YOU M,et al.Dynamic disulfide bond regulated tough adhesion and on-demand debonding of the albumin-based double network hydrogel to diverse substrates[J].ACS Applied Polymer Materials,2024,6(1):330-340.
[40] TRAN V T,MREDHA M T I,NA J Y,et al.Multifunctional poly(disulfide) hydrogels with extremely fast self-healing ability and degradability[J].Chemical Engineering Journal,2020,394:124941.
[41] TANG S X,FENG K R,YANG R,et al.Multifunctional adhesive hydrogels:from design to biomedical applications[J].Advanced Healthcare Materials,2024,14(2):2403734.
[42] YU Q,ZHENG Z R,DONG X H,et al.Mussel-inspired hydrogels as tough,self-adhesive and conductive bioelectronics:a review[J].Soft Matter,2021,17(39):8786-8804.
[43] ZHANG W,WANG R X,SUN Z M,et al.Catechol-functionalized hydrogels:biomimetic design,adhesion mechanism,and biomedical applications[J].Chemical Society Reviews,2020,49(2):433-464.
[44] XIONG Y S,ZHANG X R,MA X T,et al.A review of the properties and applications of bioadhesive hydrogels[J].Polymer Chemistry,2021,12(26):3721-3739.
[45] CHOLEWINSKI A,YANG F(KUO),ZHAO B X.Algae-mussel-inspired hydrogel composite glue for underwater bonding[J].Materials Horizons,2019,6(2):285-293.
[46] KIM M H,LEE J N,LEE J,et al.Enzymatically cross-linked poly(γ-glutamic acid) hydrogel with enhanced tissue adhesive property[J].ACS Biomaterials Science & Engineering,2020,6(5):3103-3113.
[47] CUI C Y,LIU W G.Recent advances in wet adhesives:adhesion mechanism,design principle and applications[J].Progress in Polymer Science,2021,116:101388.
[48] GAO Y,CHEN J J,HAN X Y,et al.A universal strategy for tough adhesion of wet soft material[J].Advanced Functional Materials,2020,30(36):2003207.
[49] ZHANG C,WU B H,ZHOU Y S,et al.Mussel-inspired hydrogels:from design principles to promising applications[J].Chemical Society Reviews,2020,49(11):3605-3637.
[50] HE X Y,LIU L Q,HAN H M,et al.Bioinspired and microgel-tackified adhesive hydrogel with rapid self-healing and high stretchability[J].Macromolecules,2019,52(1):72-80.
[51] ZHANG Z Z,ZHANG Y J,LIU Y S,et al.Water-retaining and separable adhesive hydrogel dressing for wound healing without secondary damage[J].Science China Materials,2023,66(8):3337-3346.
[52] DONG Y,SU J J,GUO X W,et al.Multifunctional protocatechuic acid-polyacrylic acid hydrogel adhesives for wound dressings[J].Journal of Materials Chemistry B,2024,12(27):6617-6626.
[53] WU Y,WANG Y,ZHENG C,et al.A versatile glycopeptide hydrogel promotes chronic refractory wound healing through bacterial elimination,sustained oxygenation,immunoregulation,and neovascularization[J].Advanced Functional Materials,2023,33(49):2305992.
[54] YOU M,GUO Y X,YU H,et al.Polyphenol-enhanced wet adhesive hydrogel with synergistic mechanical activation and ROS scavenging for accelerating diabetic wound healing[J].Chemical Engineering Journal,2024,500:157103.
[55] LI Q Q,WANG D,XIAO C S,et al.Advances in hydrogels for periodontitis treatment[J].ACS Biomaterials Science & Engineering,2024,10(5):2742-2761.
[56] 靳昕欣.透明质酸凝胶涂敷粘附牙周应用效果比较[J].粘接,2023,50(4):96-99.JIN X X.Comparison of the application effect of hyaluronic acid gel in the treatment of periodontitis by adhering[J].Adhesion,2023,50(4):96-99.
[57] 郭娅姣,谢咏梅,徐骏疾,等.海藻酸钠口腔用水凝胶辅助治疗Ⅱ/Ⅲ期牙周炎的短期疗效观察[J].北京口腔医学,2021,29(5):282-286.GUO Y J,XIE Y M,XU J J,et al.A short-term evaluation of effect of sodium alginate oral hydrogel as adjunctive treatment for the periodontitis grading of Ⅱ/Ⅲ[J].Beijing Journal of Stomatology,2021,29(5):282-286.
[58] CHEN H G,ZHAO Z F,ZHANG R,et al.Adaptable hydrogel with strong adhesion of wet tissue for long-term protection of periodontitis wound[J].Advanced Materials,2024,37(1):2413373.
[59] 赵洁晨,任乐,魏玉,等.一种固有抗菌的黏附性可注射水凝胶用于牙周炎骨缺损治疗的初步研究[J].口腔医学,2023,43(11):989-995.ZHAO J C,REN L,WEI Y,et al.An inherent antibacterial adhesive injectable hydrogel for the treatment of periodontitis bone defects[J].Stomatology,2023,43(11):989-995.
[60] 欧阳明,王国华.载锌基沸石咪唑的疏基化海藻酸钙复合水凝胶治疗大鼠牙周炎的实验研究[J].上海口腔医学,2022,31(4):379-383.OUYANG M,WANG G H.Application of sulfylated calcium alginate composite hydrogel loaded with zinc-based zeolite imidazole for the treatment of periodontitis[J].Shanghai Journal of Stomatology,2022,31(4):379-383.
[61] QI J Q,YU T Q,HU B Y,et al.Current biomaterial-based bone tissue engineering and translational medicine[J].International Journal of Molecular Sciences,2021,22(19):10233.
[62] ZHANG F X,LIU P,DING W,et al.Injectable mussel-inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration[J].Biomaterials,2021,278:121169.
[63] LI C D,WANG K,LI T,et al.Patient-specific scaffolds with a biomimetic gradient environment for articular cartilage-subchondral bone regeneration[J].ACS Applied Bio Materials,2020,3(8):4820-4831.
[64] LIU T L,HAO Y,ZHANG Z X,et al.Advanced cardiac patches for the treatment of myocardial infarction[J].Circulation,2024,149(25):2002-2020.
[65] XU Q X,XIAO Z Y,YANG Q Z,et al.Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction[J].Materials Today Bio,2024,25:100978.
[66] CHEN P E,ZHANG W,FAN X L,et al.A polyphenol-derived redox-active and conductive nanoparticle-reinforced hydrogel with wet adhesiveness for myocardial infarction repair by simultaneously stimulating anti-inflammation and calcium homeostasis pathways[J].Nano Today,2024,55:102157.
[67] TAN Y,NIE Y L,ZHENG W L,et al.Comparative effectiveness of myocardial patches and intramyocardial injections in treating myocardial infarction with a MitoQ/hydrogel system[J].Journal of Materials Chemistry B,2024,12(24):5838-5847.
[68] ZHENG Y T,BAIDYA A,ANNABI N.Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality[J].Bioactive Materials,2023,29:214-229.
[69] BOROUMAN S,SIGAROODI F,AHMADI TAFTI S M,et al.ECM-based bioadhesive hydrogel for sutureless repair of deep anterior corneal defects[J].Biomaterials Science,2024,12(9):2356-2368.
[70] ZHAO L,SHI Z,SUN X L,et al.Natural dual-crosslinking bioadhesive hydrogel for corneal regeneration in large-size defects[J].Advanced Healthcare Materials,2022,11(21):2201576.
[71] LIU Y C,LIN Y K,LIN Y T,et al.Injectable,antioxidative,and tissue-adhesive nanocomposite hydrogel as a potential treatment for inner retina injuries[J].Advanced Science,2024,11(11):2308635.
Basic Information:
China Classification Code:R318.08;TQ427.26
Citation Information:
[1]SHU Hangqi,YU Mengqiu,HE Yulong ,et al.Research Progress on Adhesive Hydrogels in Tissue Defect Repair[J].Chemistry & Bioengineering,2026,43(08):1-8.
Fund Information:
国家自然科学基金项目(32170844); 浙江省自然科学基金项目(LQN25C100008); 台州市科技计划项目(23gya01)
2026-08-04
2026-08-04