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Glioblastoma is one of the most common primary malignant tumors in the central nervous system, characterized by diffuse and invasive growth and high invasiveness.To improve the therapeutic effect on glioblastoma, we prepared Cu2+-loaded PEGlated melanin nanoparticles Cu-MNP-PEGs with excellent photothermal conversion performance and metal chelation ability.Moreover, we characterized the physicochemical properties of Cu-MNP-PEGs by TEM and FTIR,and studied the in vivo and in vitro magnetic resonance imaging performance.Furthermore, we evaluated the in vivo and in vitro anti-tumor effects by combining photothermal therapy(PTT) and chemodynamic therapy(CDT).In addition, we explored the mechanism of cuproptosis in tumor cells by Western blot experiments, and evaluated their in vivo biocompatibility.The results show that the prepared Cu-MNP-PEGs exhibit uniform morphology and spherical distribution with a hydrodynamic particle size of approximately 33 nm and a Zeta potential of-4.6 mV,and the groups of the nanoparticles are connected by chemical bonds.Stronger signal T1-weighted images can be obtained after magnetic resonance imaging scanning of Cu-MNP-PEGs.Cu-MNP-PEGs have a strong inhibitory effect on tumor cells, and the combination with PTT is more significant.The low expression of DLAT,LIAS,and FDX1 proteins and the high expression of HSP70 protein confirm the occurrence of cuproptosis in tumor cells.The H&E staining results indicate that Cu-MNP-PEGs have good biocompatibility.
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Basic Information:
China Classification Code:TB383.1;R739.4
Citation Information:
[1]WANG Wenshuang,SHI Ying,YAN Tianchi ,et al.Cu-MNP-PEGs for Magnetic Resonance Imaging Tracking and Photothermal-Chemodynamic Therapy of Glioblastoma[J].Chemistry ＆ Bioengineering,2026,43(07):39-46.
Fund Information:
国家自然科学基金项目(82272053,82272000)
2026-07-06
2026-07-06