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Lipases constitute the most important group of biocatalysts for industrial applications.Being capable of catalyzing diverse reactions under mild conditions with high efficiency,regioselectivity and stereoselectivity,lipases are the most widely used group of biocatalysts in pharmaceutical synthesis.In recent years,much progress had been achieved by researcher on lipase catalyzed pharmaceutical synthesis.For a better understanding of this development,we reviewed recent industrial application concerning the practical use of lipases in synthesis of antiinflammatory drugs,antidepressant drugs,antibacterial drugs,anticancer drugs,vitamin drugs and their intermediates.Selected examples of achievement of optimized lipases and improved reaction conditions in novel synthetic routes were highlighted.
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Basic Information:
China Classification Code:TQ463.2
Citation Information:
[1]XIONG Xiao-long1,2,DU Peng-fei1,JIN Peng1,2,WANG Qiu-yan1,XIE Tian1(1.Center for Biomedicine and Health,Hangzhou Normal University,Hangzhou 310012,China,2.School of Life and Environmental Science,Hangzhou Normal University,Hangzhou 310036,China).Research Progresses of Synthesis of Pharmaceuticals Catalyzed by Lipases[J].Chemistry ＆ Bioengineering,2010,27(08):1-7+23.
Fund Information:
国家自然科学基金资助项目(30900253)
2010-08-25
2010-08-25