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Human OX40 and CD30 belong to the tumor necrosis factor receptor superfamily.We introduce their gene structures, protein domain characteristics, and ligand binding modes, and summarize their expression regulation patterns in immune populations such as T cells and antigen-presenting cells.Moreover, we compare and analyze the dual action mechanisms of OX40 and CD30 in autoimmune diseases and tumors.Furthermore, we systematically review the research and development progresses of targeted drugs for OX40 and CD30:in the field of autoimmune diseases, monoclonal antibodies that antagonize the OX40/OX40L interaction have shown clinical potential in indications such as moderate to severe atopic dermatitis; in the field of tumor treatment, antibody-drug conjugates targeting CD30 have achieved successful applications and promoted the development of new strategies such as bispecific antibodies and cell therapies, while agonist therapies targeting OX40 are dedicated to enhancing anti-tumor immune responses through combination therapy and novel multifunctional antibodies.By integrating basic research and clinical application, this review provides a theoretical basis and research directions for precise immunotherapy targeting inflammation, autoimmune diseases, and tumors.
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Basic Information:
China Classification Code:TQ460.1;R91
Citation Information:
[1]ZHANG Xilun,SHAO Hongwei,KE Hang.Research Progress in Pathogenic Mechanisms and Targeted Drugs of Human OX40 and CD30[J].Chemistry & Bioengineering,2026,43(06):1-9.
Fund Information:
国家科技重大专项(2017ZX09302010); 广东省普通高校创新团队项目(2023KCXTD021); 广东省自然科学基金项目(2024A1515011201)
2026-01-31
2026
2026-04-10
2026
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2026-04-29
2026-04-29
2026-04-29