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Lactic acid bacteria(LAB) are generally recognized as safe(GRAS) microorganisms.Their metabolites possess both functionality and safety, and they have the potential to produce high levels of phenyllactic acid(PLA).The biosynthesis method with LAB as the whole cell catalyst has become the mainstream technology direction due to its eco-friendliness and high product safety.However, the PLA synthesis ability of wild-type LAB is generally weak, making it difficult to meet the requirements of large-scale applications.Currently, improving the PLA production of LAB through biological and non-biological technologies has become a research hotspot.We introduce the metabolic pathway of PLA biosynthesis in LAB,and summarize strategies for increasing the PLA production of LAB from aspects such as the screening of high-yield strains, coenzymes regeneration, gene expression regulation, the application of new technologies(quorum sensing, immobilization technologies, co-culture of cells, and cryogel encapsulation, etc.),and fermentation process optimization.The study provides a reference for the green industrial production of PLA.
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Basic Information:
China Classification Code:TS201.3;TQ245.12
Citation Information:
[1]ZHANG Guo,LI Wei,ZHOU Xi ,et al.Research Progress in Biosynthesis of Phenyllactic Acid by Lactic Acid Bacteria and Its Production Improvement Strategies[J].Chemistry & Bioengineering,2026,43(07):18-25.
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宜昌市科技研究与开发项目(A23-4-001)
2026-07-06
2026-07-06