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Extraction of Pigment from Cottonseed Hulls by Ultrasonic-Assisted Deep Eutectic Solvents and Its Antioxidant Activity
CHEN Ting;LI Taihe;TIAN Xinquan;XU Shuangjiao;FANG Dan;HAN Huanyong;LIU Sha;MA Lei;We extracted the pigment from cottonseed hulls by ultrasonic-assisted deep eutectic solvents(DESs) method.Moreover, we optimized the extraction process by single-factor experiments and response surface methodologies.Furthermore, we evaluated the antioxidant activity of pigment from cottonseed hulls by the determination of the scavenging rates of DPPH and ABTS free radicals.The results show that the optimal extraction process is as follows: DESs-5(choline chloride-ethylene glycol, molar ratio of 1∶1) is adopted as the extraction solvent, the water content of DESs-5 is 11%,the solid-liquid ratio is 1∶50(g∶mL),the ultrasonic time is 63 min, the ultrasonic power is 150 W,and the ultrasonic temperature is 50 ℃.Under above conditions, the extraction amount of pigment from cottonseed hulls can reach 29.512 mg·g-1.The DESs extract of pigment from cottonsead hulls exhibits excellent antioxidant activity.Its scavenging rates for DPPH and ABTS free radicals are the highest at 79.03% and 89.82%,respectively, and its antioxidant activity is superior to that of the water extract.The study provides a scientific basis and technical support for the development and utilization of cottonseed hulls resources.
Chemotactic Performance of Glucose Oxidase-Driven Micromotors
SI Yanbing;GUAN Qiaoxin;XU Leilei;We prepared SiO2@Au-GOx Janus micromotors by sputtering a gold(Au) layer on the surface of SiO2 microspheres by using magnetron sputtering technique and loading with glucose oxidase(GOx).Moreover, we characterized the morphology and structure of the micromotors by field emission scanning electron microscope and inverted fluorescent microscope, and evaluated the motion performance.Furthermore, we investigated the chemotactic performance of the micromotors through microfluidic channel.The results show that SiO2@Au-GOx micromotors are formed by half-coating the Au layer on the surface of SiO2 microspheres to form a Janus structure and loading GOx on the opposite side, with a diameter of about 3 μm.When no glucose is added to the right side of the microfluidic channel, the motion range, displacement of mass center, and directionality of the micromotors all show a trend of first increasing and then decreasing with the increase of glucose concentration in the agar on the left side, and the best chemotactic performance is achieved at a concentration of 200 mmol·L-1.When the concentration gradient difference between the two sides of the microfluidic channel is the same, the micromotors show the same motion tendency with the increase of the initial glucose concentration on the right side, indicating that the size of the glucose concentration gradient field and the initial glucose concentration can affect the chemotactic performance of the micromotors.
Research Progress in Biosynthesis of Phenyllactic Acid by Lactic Acid Bacteria and Its Production Improvement Strategies
ZHANG Guo;LI Wei;ZHOU Xi;LI Pei;LI Ku;CHEN Xiong;Lactic acid bacteria(LAB) are generally recognized as safe(GRAS) microorganisms.Their metabolites possess both functionality and safety, and they have the potential to produce high levels of phenyllactic acid(PLA).The biosynthesis method with LAB as the whole cell catalyst has become the mainstream technology direction due to its eco-friendliness and high product safety.However, the PLA synthesis ability of wild-type LAB is generally weak, making it difficult to meet the requirements of large-scale applications.Currently, improving the PLA production of LAB through biological and non-biological technologies has become a research hotspot.We introduce the metabolic pathway of PLA biosynthesis in LAB,and summarize strategies for increasing the PLA production of LAB from aspects such as the screening of high-yield strains, coenzymes regeneration, gene expression regulation, the application of new technologies(quorum sensing, immobilization technologies, co-culture of cells, and cryogel encapsulation, etc.),and fermentation process optimization.The study provides a reference for the green industrial production of PLA.
Cu-MNP-PEGs for Magnetic Resonance Imaging Tracking and Photothermal-Chemodynamic Therapy of Glioblastoma
WANG Wenshuang;SHI Ying;YAN Tianchi;LIU Pengfei;The Fourth Hospital of Harbin Medical University;Glioblastoma is one of the most common primary malignant tumors in the central nervous system, characterized by diffuse and invasive growth and high invasiveness.To improve the therapeutic effect on glioblastoma, we prepared Cu2+-loaded PEGlated melanin nanoparticles Cu-MNP-PEGs with excellent photothermal conversion performance and metal chelation ability.Moreover, we characterized the physicochemical properties of Cu-MNP-PEGs by TEM and FTIR,and studied the in vivo and in vitro magnetic resonance imaging performance.Furthermore, we evaluated the in vivo and in vitro anti-tumor effects by combining photothermal therapy(PTT) and chemodynamic therapy(CDT).In addition, we explored the mechanism of cuproptosis in tumor cells by Western blot experiments, and evaluated their in vivo biocompatibility.The results show that the prepared Cu-MNP-PEGs exhibit uniform morphology and spherical distribution with a hydrodynamic particle size of approximately 33 nm and a Zeta potential of-4.6 mV,and the groups of the nanoparticles are connected by chemical bonds.Stronger signal T1-weighted images can be obtained after magnetic resonance imaging scanning of Cu-MNP-PEGs.Cu-MNP-PEGs have a strong inhibitory effect on tumor cells, and the combination with PTT is more significant.The low expression of DLAT,LIAS,and FDX1 proteins and the high expression of HSP70 protein confirm the occurrence of cuproptosis in tumor cells.The H&E staining results indicate that Cu-MNP-PEGs have good biocompatibility.
Adsorption Performance of Rutin Magnetic Molecularly Imprinted Polymers
GONG Naichao;GAO Qianzhizi;WU Jun;KUANG Zhenghao;YUE Wei;Taking magnetic Fe_3O4@SiO2 nanoparticles as a carrier, rutin as a template, α-methylacrylic acid as a functional monomer, and trimethylolpropane trimethacrylate as a crosslinking agent, we prepared rutin magnetic molecularly imprinted polymers(MMIPs),and investigated the adsorption performance of MMIPs.The results show that the adsorption process of rutin by MMIPs conforms to the Langmuir isothermal adsorption model and the pseudo-first-order kinetic equation.The adsorption capacity of rutin by MMIPs is 19.41 mg·g-1,the imprinting factor is 3.51,and the selectivity factors for analogues such as apigenin, luteolin, genistein, and quercetin are 2.77,3.02,2.46,and 2.18,respectively.MMIPs have a certain specific adsorption property for rutin, with a large adsorption capacity, easy desorption, and stable adsorption performance.The study provides a new idea for the separation and purification of rutin from complex systems.
Research Progress in Chemical Compositions and Pharmacological Effects of Eupatorium adenophorum Spreng.
GONG Ranran;DONG Fawu;GAO Lingxiao;WEI Yutong;ZHANG Qingwen;TIAN Yuan;WEI Shanshan;Eupatorium adenophorum Spreng.is a worldwide invasive weed that causes significant damage to the ecosystems and biodiversity of invaded areas.Modern pharmacological studies have shown that Eupatorium adenophorum Spreng.has antibacterial, antifungal, antiviral, anti-inflammatory, and anti-tumor effects.Therefore, the research approach towards Eupatorium adenophorum Spreng.has gradually shifted from eradication and control to comprehensive utilization.We review the research progress of Eupatorium adenophorum Spreng.in terms of chemical compositions(terpenoids, flavonoids, steroids, and phenylpropanoids),pharmacological effects, and toxicity.Moreover, we put forward prospects in the future research priorities.
Synthesis Progress in Norcembranoid Diterpenoids
ZENG Shanji;LI Di;LONG Ai;HE Shuzhong;The norcembranoid diterpenoid natural products possess a complex and compact tetracyclic core scaffold, consisting of a functionalized six-or seven-membered ring, along with four to eight adjacent stereogenic centers, and several unstable structural units.The norcembranoid diterpenoids exhibit biological activities such as anti-cancer, anti-inflammatory, and cytotoxicity.We summarize the synthesis progress of norcembranoid diterpenoid natural products in recent years, including scabrolide A,yonarolide, sinulochmodin C,and ineleganolide.
Preparation and Electrochemical Performance of Na_2Ti_3O7 Anode Material for Sodium Ion Battery
ZHAO Xiaoxue;ZHAO Bo;JI Chaowei;JIANG Hongbo;DOU Shumei;TIAN Meijuan;FAN Yi;ZHAO Weixing;We prepared the anode materials Na_2Ti_3O7(referred to as M-NTO and S-NTO) for sodium ion battery by a molten salt method and a sol-gel method, respectively.Moreover, we characterized their physicochemical properties by XRD,FTIR,Raman, SEM,EDS-mapping, and XPS,and studied their electrochemical performance.The results show that S-NTO prepared by the sol-gel method is significantly superior to M-NTO prepared by the molten salt method in terms of crystallinity, uniformity of grain size, and phase purity.At a rate of 0.5 C and a voltage range of 0.01-2.50 V,the first-cycle charge and discharge specific capacities of S-NTO battery are 78.9 and 61.4 mAh·g-1,respectively.After cycling 5 cycles at a rate of 5 C,the specific capacity decay of S-NTO battery is only 3.4 mAh·g-1.Under the same measurement conditions, the battery assembly using S-NTO anode material has the smaller charge transfer resistance.The sol-gel method has significant advantages in regulating the microstructure of anode materials.The highly ordered crystal structure and uniform particle size of the anode material can effectively inhibit the structural degradation during the cycling process, thereby improving its long-term stability.
Formula Screening and Performance Evaluation on Solid-Free High-Density Phosphate Test Fluid for Deep Water
SUN Jingkang;WANG Runbo;LIANG Zhaojian;LIU Shujie;XU Yilong;WEI Anchao;YUE Qiansheng;We studied the feasibility of potassium-based phosphate as a weighting agent for solid-free high-density test fluid, and optimized the formula of phosphate test fluid.Moreover, we evaluated its performance.The results show that potassium-based phosphate has the characteristics of moderate cost, wide sources, and large solubility, and the density can be adjusted to above 1.700 g·cm-3.According to the viscosity-enhancing effect and low-temperature rheology of potassium-based phosphate solution, potassium pyrophosphate with low viscosity effect is selected as the weighting agent of test fluid, and the formula of test fluid is optimized as follows: fresh water+0.15% chelating agent+0.15% cleanup additive+0.30% corrosion inhibitor, and the density can be adjusted between 1.000—1.820 g·cm-3.The solid-free high-density phosphate test fluid has a low crystallization point, low corrosion, and excellent reservoir protection performance, which can meet the test requirements of deep water/ultra-deep water high-temperature and high-pressure oil and gas reservoirs, and has broad application prospects.
Efficient Adsorption of Glyphosate by Cerium Oxide-Modified Coconut Shell Biochar and Its Mechanism
LI Songyan;YI Xingguo;YU Shuilian;DENG Cuiwen;HUANG Yingping;HUANG Di;LIU Honglin;Using Ce(NO3)3 and coconut shell biochar(CBC) as raw materials, we prepared cerium oxide-modified coconut shell biochar(CO-CBC) via co-precipitation-high-temperature calcination method, and characterized its structure by SEM,EDS,N2 adsorption-desorption isotherm, and pore size distribution curve.Moreover, we studied the adsorption performance of CO-CBC on Glyphosate by using the kinetic model and the isothermal adsorption model, and systematically investigated the effects of CO-CBC dosage, pH value, and co-existent in water on the adsorption process.Furthermore, we revealed the adsorption mechanism by in situ FTIR and surface charge analysis.The results show that CO-CBC has a rough and porous morphology, and its adsorption capacity is 5.66 times that of CBC treated with the same calcination temperature(400-CBC).The adsorption of Glyphosate by CO-CBC is consistent with the pseudo-first-order, pseudo-second-order kinetic models and Freundlich isothermal adsorption model, and the adsorption process includes physical adsorption and multi-molecular layer chemisorption on non-uniform surfaces.CO-CBC binds to the carboxyl and amine groups of Glyphosate through the Ce sites, which is affected by charge effect.This study provides a new strategy for efficient removal of Glyphosate in water.